Jeuveau® (prabotulinintoxinA-xvfs) For Temporary Treatment Of Frown Lines: 5 Things to Consider Before Your Neurotoxin Treatment

Want to diminish those persistent frown lines (aka glabellar lines, aka “11s”) between the brows, but don’t want to end up with frozen face or looking unnatural from a neurotoxin treatment? You’re in luck. The aesthetics market has come a long way in recent years. In the hands of a skilled injector, you can achieve just the look you want, without looking overdone or unlike yourself.

If you’re looking to achieve a natural-looking result—one where you can still express yourself without frown lines—consider Jeuveau® (prabotulinintoxinA-xvfs). Manufactured in South Korea (the beauty capital of the world) for the performance beauty company Evolus®, Jeuveau is a prescription pharmaceutical neurotoxin indicated for the temporary treatment of moderate to severe glabellar lines, or as they’re often described on social media and in treatment rooms across the country, the “11s”. (Because at maximum frown, they often look like the number eleven.)

Like all neurotoxins, Jeuveau must be administered by a medical professional with proper training. To find a Jeuveau specialist, go here.

Below, New York dermatologist Amy Wechsler, MD—who performs neurotoxin injections and other aesthetic treatments every day—shares five reasons to expect more from your neurotoxin when treating your 11s and what to consider before heading in for your tox appointment.

1. Not all injectors are created equal

Your treatment begins with your injector, which is why Wechsler recommends doing your homework, researching injectors in your area and determining whose background, experience, results and technique resonate with you.

“Before you’re even in the consult room asking questions, you’ve ideally done your research, asked friends and gone online to find an experienced injector,” says Dr. Wechsler. “At all costs, avoid going to a popup location in a strip mall or other temporary location that makes it difficult to vet the injectors or clinic,” she adds.

If you’re unsure where to start, the Jeuveau® website features an easy-to-use search tool to help locate an experienced injector near you.

When you arrive for your appointment and you’re in the chair, your education continues. “The most important thing you can do when working with a new injector is clearly communicate your desired results and the look you want to achieve,” says Dr. Wechsler. “Ask if they feel comfortable recommending and performing treatment that can achieve those results.”

2. Don’t settle for the frozen look

Once you’ve selected an injector you trust, achieving a natural-looking result (no frown lines with freedom to still express yourself) is up to their expertise, technique and the neurotoxin they use, especially to help avoid the more frozen look popularized over a decade ago. Jeuveau’s manufacturing process helps keep it more than 95% pure, which leads to predictable results. In the hands of a skilled injector, Jeuveau is injected precisely where you want it for smooth, natural looking results, minus those 11s.

“In my experience, most of today’s patients don’t want to look frozen,” says Dr. Wechsler. If you fall into this camp, clarify up front with your injector the look you’re going for and the results you desire. For example, “I still want to be able to move my face,” or “I want to be able to move my eyebrows up and down” are great places to start.

Like all aesthetic treatments and procedures, the best results aren’t jarring. “You don’t want someone to look at your face and think, ‘Oh wow, she got over-injected with neurotoxins,’” says Dr. Wechsler.

“Instead, you want a result that has others saying ‘Wow, you look really rested. Did you just get back from vacation or the spa?’ Ultimately, the best results aren’t that obvious. You just look refreshed and rested.”

3. It’s an individualized treatment

When it comes to neurotoxin injections and results, Dr. Wechsler says there’s no one formula for everyone, adding, “A skilled injector understands that every face is unique and treatment should be based on your facial anatomy, age, aesthetic goals and personal preference.”

(Think of getting injected as a marriage of art and science. The science is the product and proven patient satisfaction the neurotoxin delivers. The art is how your chosen specialist injects the product to achieve best possible results for you.)

If you are allergic to any of the ingredients in the neurotoxin your injector chooses to use, have had an allergic reaction to a botulinum toxin product, or have a skin infection at the planned injection site, then don’t get a neurotoxin treatment. During your consult, be sure to tell your injector about all your medical conditions, especially if you have any muscle or nerve conditions which can increase risks with treatment. For more information about treatment risks, please see the Summary of Important Information for Jeuveau below.

4. Look for fast-acting, long-lasting results

Not all neurotoxins are the same. Some neurotoxins take longer to kick in than others. About 50% of patients treated with Jeuveau® start to see results in as little as two days.

“In my experience, people tend to notice results in the first week,” says Dr. Wechsler, adding, “Over the next two weeks, you’ll gradually see more visual improvement. Maximum results are observed at Day 30.”

As with any neurotoxin, results with Jeuveau fade over time. After 3-4 months, you’ll want to get your 11s retreated. On average, Jeuveau patients receive 3 treatments per year.

5. On a budget? Look for ways to save money on every treatment

Like any aesthetic treatment, opting for neurotoxin injections is an ongoing investment. To maintain your results, plan for that investment to recur every 3-4 months. Before getting treatment, check to see if the neurotoxin you choose offers a loyalty program with patient savings. When you sign up for Evolus Rewards, you join a loyalty program that gives you $40 off your Jeuveau by Evolus treatment every 90- 120 days. To learn more about Evolus Rewards, go here.

Whether you’re interested in neurotoxins for the first time or are looking to try something new, be sure to ask your injector about Jeuveau (pronounced Jū vō).

Please see Summary of Important Information, including Boxed Warning, below.

Summary of Important Informa�on for JEUVEAU® (prabotulinumtoxinA–xvfs) for injec�on

• have drooping eyelids
• are pregnant or breas�eeding, or plan to become pregnant or breas�eed. It is not known if JEUVEAU can harm your unborn baby or passes into breast milk

What should I tell my healthcare provider about medicines or vitamins I take?

Tell your healthcare provider about all the medicines you take, including prescrip�on and over-the-counter medicines, vitamins and herbal supplements. Using JEUVEAU with certain other medicines may cause serious side effects. Do not start any new medicines un�l you have told your healthcare provider that you have received JEUVEAU in the past.

Especially tell your healthcare provider if you: have received any other botulinum toxin product in the past and last 4 months, and exactly which product you received (such as BOTOX, BOTOX Cosme�c, MYOBLOC, DYSPORT, or XEOMIN).

What are the possible side effects of JEUVEAU?

JEUVEAU can cause other serious side effects, including:
• Allergic reactions (such as itching, rash, red itchy welts, wheezing, asthma symptoms, trouble breathing, dizziness, or feeling faint). Tell your healthcare provider or get emergency medical help right away if you develop wheezing or trouble breathing, or if you feel dizzy or faint
• Heart problems. Irregular heartbeat and heart attack that have caused death, have happened in some people who received botulinum toxin products
• Eye problems (including dry eye, reduced blinking, and corneal problems). Tell your healthcare provider if you develop eye
pain or irritation, sensitivity to light, or changes in your vision

The most common side effects of JEUVEAU include: headache, eyelid drooping, upper respiratory tract infection, and increased white blood cell count in your blood.

These are not all the possible side effects of JEUVEAU. Call your healthcare provider for medical advice if you have any side effect that bothers you or does not go away.

Where can I find more information about JEUVEAU?

This is a brief summary of safety information about JEUVEAU and is not comprehensive. For more information about JEUVEAU, see the full Prescribing Information including BOXED WARNING, and Medication Guide, visit Evolus.com or talk to your healthcare provider.

To report side effects associated with use of JEUVEAU, please call 1-877-EVOLUS1/1-877-386-5871. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit htp://www.fda.gov/medwatch or call 1-800-FDA-1088.

Exclusively licensed and manufactured for:
Evolus, Inc., 520 Newport Center Drive, Suite 1200, Newport Beach, CA 92660

©2023 Evolus, Inc. All rights reserved. All trademarks are the property of their respective owners.

US-JUV-2300118

What is the most important information I should know about JEUVEAU?
JEUVEAU may cause serious side effects that can be life threatening. Call your healthcare provider or get medical help right away if you have any of these problems after treatment with JEUVEAU:
• Problems swallowing, speaking, or breathing. These problems can happen hours, days, or weeks after an injection of JEUVEAU if the muscles that you use to breatheand swallow become weak after the injection. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with JEUVEAU. You are at the highest risk if these problems are pre-existing before injection.

• Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause serious symptoms, including: loss ofstrength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing.

These problems could make it unsafe for you to drive a car or do other dangerous activities.

What is JEUVEAU?

JEUVEAU is a prescription medicine that is injected into muscles and used in adults for a short period of time (temporary) to improve the look of moderate to severe frown lines between the eyebrows (glabellar lines).

It is not known if JEUVEAU is safe and effective for use in children.

JEUVEAU dosing units are not the same as, or comparable to, any other botulinum toxin product.

Who should not use JEUVEAU?

Do not use JEUVEAU if you:
• are allergic to any of the ingredients in JEUVEAU such as botulinum toxin type A and human serum albumin
• had an allergic reaction to any other botulinum toxin product such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA (BOTOX®/BOTOX® Cosmetic), abobotulinumtoxinA (DYSPORT®), or incobotulinumtoxinA (XEOMIN®)
• have a skin infection at the planned injection site

What should I tell my healthcare provider before treatment with JEUVEAU?
Tell your healthcare provider about all your medical conditions, including if you:

• have a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], Myasthenia gravis or Lambert-Eaton syndrome) as you may be at increased risk of serious side effects

• had any side effect from any botulinum toxin product in the past, including dry eye
• have or have had problems with breathing (such as asthma or emphysema), swallowing, bleeding, or your heart
• plan to have or have had surgery on your face
• have weakness of your forehead muscles, such as trouble raising your eyebrows