Can the Acne Drug Replace Surgery?


Last year, a string of TikTok videos clued us in on how the acne drug isotretinoin, or Accutane, resulted in what users called an “Accutane Nose Job.” Countless content creators have documented their smaller, narrower-looking noses after a few months on the drug. Although it may seem like a fascinating TikTok discovery, Campbell, CA plastic surgeon R. Laurence Berkowitz, MD says facial surgeons have studied the drug’s reshaping abilities and are using it in conjunction with rhinoplasties now.

The Accutane “Nose Job”

So, how does “Accutane Nose Job” work? “It’s important to note that the use of Accutane outside of its prescribed use, usually for acne, is not recommended and highly dangerous,” explains Smithtown, NY facial plastic surgeon James C. Marotta, MD. “It works by inhibiting sebum production, or oil, in the skin and decreasing the sebaceous gland size. Theoretically, someone with thick skin will see improvement but by no means is it a ‘nose-job.’” 

Current president of The Rhinoplasty Society, Palo Alto, CA facial plastic surgeon Sam P. Most, MD says many users may notice a smaller nasal tip after use. “The skin of the nasal tip and Ala, or the nostrils, has a lot of sebaceous glands,” he says. “Thus, it can cause these to shrink and thins the skin, which can will lead to a smaller tip.”

“This is not new news,” adds Spokane, WA dermatologist Wm. Philip Werschler, MD. “The ‘Accutane Nose Job’ notion, or that Isotretinoin works this way is old actually. It only works for people with sebaceous gland hyperplasia, or big, overgrown oil glands in the nose, chin and forehead.” Dr. Werschler adds that it’s been a Hollywood secret for years. “This started in the film industry several decades ago,” he says. “Studio dermatologists prescribed low doses to young actors on set to reduce oil production to ensure on-camera makeup looks fresher, longer.”